Colleen Cutcliffe (on the microbiome)

Episode overview

Colleen Cutcliffe (Pendulum Therapeutics) is a doctor of biochemistry and microbiology and CEO and co-founder of Pendulum Therapeutics. Colleen joins the Armchair Expert to discuss starting a microbiome supplement company inspired by her premature daughter who had to take antibiotics, applying hyenas' evolved ability to digest rotting meat to study gut bacteria, and how fecal transplants reliably help treat C. diff. Colleen and Dax talk about the real linkages between microbiome and depression, obesity, and more, how the body’s natural GLP1s function, and why a healthy gut is a resilient gut. Colleen explains her wooden fence analogy to illustrate leaky guy syndrome, remarkable results from experiments giving mice Akkermansia, and that the beauty of the microbiome is that everything is recoverable.

Episode descriptions and transcript text can contain errors. Verify important details against the original recording.

Short transcript highlights

These brief excerpts are navigation aids selected from different points in the transcript.

1. 0:00Tell me what you know about the microbiome. Well, I read I contain multitudes, which I feel like puts me
2. 35:45the changing the box of the environment is infinitely more successful in anything you would tackle. So even GLP1,
3. 1:11:46This is great. Yeah. Thank you so much. Our pleasure. Yeah. Great to meet you. Good luck with everything. Thank you."